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Dr Matilde Vaghi

Dr Matilde Vaghi

Office Phone: (7)64759

Departments and Institutes


Research Interests

Matilde is taking advantage of well defined, standardized cross-species paradigms and innovative imaging techniques to precisely characterize patterns of abnormalities within fronto-striatal circuits in OCD patients. Aim of Matilde’s work is to test whether altered connectivity can be found in specific fronto-striatal loops in OCD patients and, crucially, to relate such disconnectivity to objective measures related to the compulsivity construct, such as cognitive flexibility and goal-directed behaviour. 


  • cognitive
  • neuroimaging
  • neural circuit
  • connectivity
  • psychiatry
  • prefrontal
  • network

Key Publications

Vaghi, M.M., Luyckx, F., Sule, A., Fineberg, N.A., Robbins, T.W., and De Martino, B. (2017). Compulsivity Reveals a Novel Dissociation between Action and Confidence. Neuron 96, 348–354.e4.

Vaghi, M. M., Hampshire, A., Fineberg, N. A., Kaser, M., Brühl, A. B., Sahakian, B. J., Chamberlain, S.R., Robbins, T.W. (2017). Hypoactivation and dysconnectivity of a frontostriatal circuit during goal-directed planning as an endophenotype for Obsessive-Compulsive Disorder. Biological psychiatry: cognitive neuroscience and neuroimaging, 0(0). in press

Tettamanti, M., Vaghi, M. M., Bara, B. G., Cappa, S. F., Enrici, I., & Adenzato, M. (2017). Effective connectivity gateways to the Theory of Mind network in processing communicative intention. Neuroimage155, 169–176.

Vaghi, M. M., Vértes, P. E., Kitzbichler, M. G., Apergis-Schoute, A. M., van der Flier, F. E., Fineberg, N. A., Sule, A., Zaman, R., Voon, V., Kundu, P., Bullmore, E.T., Robbins, T.W. (2017). Specific Frontostriatal Circuits for Impaired Cognitive Flexibility and Goal-Directed Planning in Obsessive-Compulsive Disorder: Evidence From Resting-State Functional Connectivity. Biological psychiatry, 81(8), 708–717.

Ghio, M., Vaghi, M. M. , Perani, D., & Tettamanti, M. (2016). Decoding the neural representation of fine-grained conceptual categories. Neuroimage132, 93–103.

Ghio, M.*, Vaghi, M. M.*, & Tettamanti, M. (2013). Fine-grained semantic categorization across the abstract and concrete domains. Plos one8(6), e67090.

Book Chapters

Vaghi MM, Robbins TW. (2017) Functional Imaging Studies of Obsessive Compulsive Disorder: A Hypothesis-Driven Review. In Obsessive-Compulsive Disorder: Phenomenology, Pathophysiology, and Treatment. Ed. C. Pittenger. Oxford University Press.