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Dr Simon Stott


I am interested in the development, maintenance and functioning of subsets of midbrain dopamine neurons, with a particular interest in Parkinson's disease.

My current lab work involves two lines of research:

The first is investigating the possible role the glycoprotein CD24 has in the selective cell death observed in Parkinson’s disease. The goal of this work is to identify novel therapeutic targets for Parkinson’s disease.

The second line of research is examining gene expression in dopamine neurons in the human midbrain as part of an EU-wide consortium (DDPDgenes). This work is determining if developmentally expressed genes have any function in Parkinson’s disease.

I also help out in the clinic, conducting cognitive assessments on people with Parkinson's disease.

Departments and Institutes

Clinical Neurosciences:

Research Interests

Parkinson's disease and midbrain dopamine neurons

Key Publications

Stott SR, Barker RA (2014), “Time course of dopamine neuron loss and glial response in the 6-OHDA striatal mouse model of Parkinson's disease.” Eur J Neurosci 39(6):1042-56

Stott SR, Metzakopian E, Lin W, Kaestner KH, Hen R, Ang SL (2013), “Foxa1 and foxa2 are required for the maintenance of dopaminergic properties in ventral midbrain neurons at late embryonic stages.” J Neurosci 33(18):8022-34

Kornum BR, Stott SR, Mattsson B, Wisman L, Ettrup A, Hermening S, Knudsen GM, Kirik D (2010), “Adeno-associated viral vector serotypes 1 and 5 targeted to the neonatal rat and pig striatum induce widespread transgene expression in the forebrain.” Exp Neurol 222(1):70-85 

Hebsgaard JB, Nelander J, Sabelström H, Jönsson ME, Stott S, Parmar M (2009), “Dopamine neuron precursors within the developing human mesencephalon show radial glial characteristics.” Glia 57(15):1648-58