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Dr Kirsten Scott MA,MBBS,Mphil, MRCP

Dr Kirsten Scott, MA,MBBS,Mphil, MRCP

PhD candidate

Wellcome Trust PhD Program for Clinicians

Honorary neurology SPR (Cambridge University Hospitals NHS Trust)

Clinical supervisor for undergraduate clinical students (Churchill College, Lucy Cavendish College)

Supervisor for undergraduate neurobiology of human behaviour (Part 1b) (Pembroke College)


Departments and Institutes

Clinical Neurosciences:

Research Interests

I have previously worked on the epidemiology and genetics of Amyotrophic Lateral Sclerosis and am now interested in the role of the immune system in disease progression in neurodegenerative disease. Specifically,  I am studying the role played by B lymphocytes in Parkinson's disease working across two labs on the Addenbrooke's site combining basic immunology with clinical neuroscience. 

Key Publications

Al-Chalabi A, Calvo A, Chio A, Colville S, Ellis CM, Hardiman O, Heverin M, Howard RS, Huisman MH, Keren N, Leigh PN, Mazzini L, Mora G, Orrell RW, Rooney J, Scott KM, Scotton WJ, Seelen M, Shaw CE, Sidle KS, Swingler R, Tsuda M, Veldink JH, Visser AE, van den Berg LH, Pearce N. Analysis of amyotrophic lateral sclerosis as a multistep process: a population-based modelling study. Lancet Neurol. 2014 Nov;13(11):1108-13. doi: 10.1016/S1474-4422(14)70219-4.

 

Keren N, Scott KM, Tsuda M, Barnwell J, Knibb JA, Ellis CM, Leigh PN, Shaw CE, Al-Chalabi A. Evidence of an environmental effect on survival in ALS. Amyotroph Lateral Scler Frontotemporal Degener. 2014 May 27:1-6

 

Jones AR, Woollacott I, Shatunov A, Cooper-Knock J, Buchman V, Sproviero W, Smith B, Scott KM, Balendra R, Abel O, McGuffin P, Ellis CM, Shaw PJ, Morrison KE, Farmer A, Lewis CM, Leigh PN, Shaw CE, Powell JF, Al-Chalabi A. Residual association at C9orf72 suggests an alternative amyotrophic lateral sclerosis-causing hexanucleotide repeat. Neurobiol Aging. 2013 Sep;34(9):2234.e1-7.

 

Smith BN, Newhouse S, Shatunov A, Vance C, Topp S, Johnson L, Miller J, Lee Y, Troakes C, Scott KM et al. The C9ORF72 expansion mutation is a common cause of ALS+/-FTD in Europe and has a single founder. European journal of human genetics : EJHG 2012 Jun;(February):1-7.

Scotton WJ, Scott KM, Moore DH, Almedom L, Wijesekera LC, Janssen A, Nigro C, Sakel M, Leigh PN, Shaw C A-CA. Prognostic categories for amyotrophic lateral sclerosis. Amyotrophic lateral sclerosis 2012;June 7(E pub ahead of print)

Roche J.C., Rojas-Garcia R., Scott K.M., Scotton W., Ellis C.E., Burman R., Wijesekera L., Turner M.R., Leigh P.N., Shaw C.E., Al-Chalabi A. A proposed staging system for amyotrophic lateral sclerosis. Brain. 2012 Mar;135(Pt 3):847-52

 

Rojas-Garcia R., Scott K.M.*, Roche J.C., Scotton W., Martin N., Janssen A., Goldstein L.H., Leigh P.N., Ellis C.M., Shaw C.E., Al-Chalabi A. No evidence for a large difference in ALS frequency in populations of African and European origin: a population based study in inner city London. Amyotroph Lateral Scler. 2012 Jan;13(1):66-8.

*Joint first author

 

Hanby M.F, Scott K.M., Scotton W., Wijesekera W., Mole T., Ellis C.E., Leigh  P.N., Shaw C.E., Armon C., Al-Chalabi, A. The risk to first degree relatives of patients diagnosed with sporadic ALS. Brain (2011) 134 :3454-7

 

Scott, K. M. Evidence Based Medicine: keeping up to date online. Student BMJ 2010;18:c3173

*Commissioned by the student BMJ, paid £150.

 

Scott, K.M., Abhinav, K.,Wijesekera, L., Ganesalingam, J.,Goldstein, L.H., Janssen, A. et al.

The association between ALS and population density: a population based study. Amyotrophic Lateral Sclerosis.

Amyotroph Lateral Scler. 2010 Apr 29

 

Manjaly, Z. R*., Scott, K.M*., Abhinav, K.,Wijesekera, L., Ganesalingam, J.,Goldstein, L.H., Janssen, A. et al. The sex ratio in amyotrophic lateral sclerosis and menopause: a population-based study. Amyotrophic Lateral Sclerosis. Amyotroph Lateral Scler. 2010 Mar 12

*Joint first author

 

Scott, K. M., Parker, F., Heckmann, J. Opsoclonus myoclonus and HIV infection. Journal of Neurological Sciences. (2009) 15 ;284(1-2):192-5

 

Scott, K. M., Abhinav, K. Stanton, B. R., Johnstone, C., Turner, M. R., Ampong, M-A., Sakel, M., Orrell, R. W., Howard, R., Shaw, C. E., Leigh, P. N., Al-Chalabi, A.  Geographical Clustering of Amyotrophic Lateral Sclerosis in South East England: A Population Study. Neuroepidemiology. (2009);32(2):81-8.

 

Somner J.E., Stone N., Koukkoulli A., Scott KM, Field A.R., Zygmunt J. Surgical scrubbing: can we clean up our carbon footprints by washing our hands? J Hosp Infect. 2008 Nov;70(3):212-5.

 

Somner, J. E. A., Morris, D. S., Scott, K. M., MacCormick, I. J. C., Aspinall, P., &  Dhillon, B. (2007) What happens to intraocular pressure at altitude? Investigative Ophthalmology and Visual Sciences. 48(4):1622-6

 

Morris, D. S., Somner, J. E. A., Scott, K. M., MacCormick, I. J. C., Aspinall, P., &  Dhillon, B. (2007) Corneal thickness at high altitude. Cornea 26(3):308-11

 

Somner, J. E. A, Scott, K. M., Gibb, A. P. (2007) What is the optimum location of alcohol based hand cleanser? Infection Control and Hospital Epidemiology. 28(1):108-9

 

Scott, K. M., de Wit, I. & Deary, I. J. (2006). Spotting books and countries: New approaches to estimating and conceptualizing prior intelligence. Intelligence 34, 429 – 436.

 

Simner J, Mulvenna C, Sagiv N, Tsakanikos E, Witherby S A, Fraser C, Scott, K., Ward J. (2006). Synaesthesia: The prevalence of atypical cross-modal experiences. Perception 35 (8) 1024 – 1033

 

Morris, D. S., Somner, J. E. A., Scott, K.M., McCormick, I.J.C., Dhillon, B., Huang, S. S. (2006) Retinal vascular features at high altitude. High Altitude Medicine and Biology  7(4): 337-8

 

Somner, J. E. A, Scott, K. M., McCormick, I. J. C., Dhillon, B. and Morris, D.S. Measuring intraocular pressure at high altitude. High Altitude Medicine and Biology 2006; 7(4): 346