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Dr Andrea Mariana Santangelo

Dr Andrea Mariana Santangelo

Research Associate

Office Phone: (3)39012 (3)33589

Research Interests

My work focuses on gene variability and emotional and cognitive behaviour interactions. In particular, I study variation in the serotonin transporter gene that has been linked to vulnerability to early-life stress and the development of affective disorders. Our research includes behavioural testing, brain imaging and molecular studies to understand the molecular mechanisms and neurodevelopmental changes that underlie the individual differences in affective behaviour.

Key Publications


Shiba Y, Santangelo AM, Braesicke K, Agustín-Pavón C, Cockcroft G, Haggard M, Roberts AC (2014), “Individual differences in behavioral and cardiovascular reactivity to emotive stimuli and their relationship to cognitive flexibility in a primate model of trait anxiety.” Front Behav Neurosci 8:137Details


Agustín-Pavón C, Braesicke K, Shiba Y, Santangelo AM, Mikheenko Y, Cockroft G, Asma F, Clarke H, Man MS, Roberts AC (2012), “Lesions of ventrolateral prefrontal or anterior orbitofrontal cortex in primates heighten negative emotion.” Biol Psychiatry 72(4):266-72 Details


Bumaschny VF, de Souza FS, López Leal RA, Santangelo AM, Baetscher M, Levi DH, Low MJ, Rubinstein M (2007), “Transcriptional regulation of pituitary POMC is conserved at the vertebrate extremes despite great promoter sequence divergence.” Mol Endocrinol 21(11):2738-49 Details

Santangelo AM, de Souza FS, Franchini LF, Bumaschny VF, Low MJ, Rubinstein M (2007), “Ancient exaptation of a CORE-SINE retroposon into a highly conserved mammalian neuronal enhancer of the proopiomelanocortin gene.” PLoS Genet 3(10):1813-26 Details


de Souza FS, Santangelo AM, Bumaschny V, Avale ME, Smart JL, Low MJ, Rubinstein M (2005), “Identification of neuronal enhancers of the proopiomelanocortin gene by transgenic mouse analysis and phylogenetic footprinting.” Mol Cell Biol 25(8):3076-86 Details


Overstreet LS, Hentges ST, Bumaschny VF, de Souza FS, Smart JL, Santangelo AM, Low MJ, Westbrook GL, Rubinstein M (2004), “A transgenic marker for newly born granule cells in dentate gyrus.” J Neurosci 24(13):3251-9 Details