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Nicole Horst

Office Phone: (3)39012

Departments and Institutes


Research Interests

I am interested in investigating the role of cortico-striatal circuits in flexible behaviour in order to understand how disruption of these circuits and their modulation by various neurotransmitters may underpin the inflexible behaviours observed in conditions like Obsessive-Compulsive Disorder.

Key Publications

Clarke HF, Horst NK, Roberts AC (2015), “Regional inactivations of primate ventral prefrontal cortex reveal two distinct mechanisms underlying negative bias in decision making.” Proc Natl Acad Sci U S A 112(13):4176-81.

Horst NK, Laubach M (2013), “Reward-related activity in the medial prefrontal cortex is driven by consumption.” Front Neurosci 7:56.

Caetano MS, Horst NK, Harenberg L, Liu B, Arnsten AF, Laubach M (2012), “Lost in transition: aging-related changes in executive control by the medial prefrontal cortex.” J Neurosci 32(11):3765-77.

Horst NK, Heath CJ, Neugebauer NM, Kimchi EY, Laubach M, Picciotto MR (2012), “Impaired auditory discrimination learning following perinatal nicotine exposure or β2 nicotinic acetylcholine receptor subunit deletion.” Behav Brain Res 231(1):170-80.

Horst NK, Laubach M (2012), “Working with memory: evidence for a role for the medial prefrontal cortex in performance monitoring during spatial delayed alternation.” J Neurophysiol 108(12):3276-88.

Heath CJ, Horst NK, Picciotto MR (2010), “Oral nicotine consumption does not affect maternal care or early development in mice but results in modest hyperactivity in adolescence.” Physiol Behav 101(5):764-9.

Smith NJ, Horst NK, Liu B, Caetano MS, Laubach M (2010), “Reversible Inactivation of Rat Premotor Cortex Impairs Temporal Preparation, but not Inhibitory Control, During Simple Reaction-Time Performance.” Front Integr Neurosci 4:124.

Horst NK, Laubach M (2009), “The role of rat dorsomedial prefrontal cortex in spatial working memory.” Neuroscience 164(2):444-56.

Narayanan NS, Horst NK, Laubach M (2006), “Reversible inactivations of rat medial prefrontal cortex impair the ability to wait for a stimulus.” Neuroscience 139(3):865-76.

Lambe EK, Olausson P, Horst NK, Taylor JR, Aghajanian GK (2005), “Hypocretin and nicotine excite the same thalamocortical synapses in prefrontal cortex: correlation with improved attention in rat.” J Neurosci 25(21):5225-9.