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Dr Dennis Chan BSc PhD MB BChir MD FRCP

Dr Dennis Chan, BSc PhD MB BChir MD FRCP

University Lecturer and Honorary Consultant in Clinical Neurosciences


Office Phone: (7)60696

Biography:

I am interested in identifying alterations in the function of the entorhinal cortex (EC) and hippocampus in early Alzheimer's disease (AD), with the ultimate aim of diagnosing AD prior to symptom onset. 

EC grid cell and hippocampal place cell function and their behavioural correlates will be studied in collaboration with Nobel Laureate Professor John O’Keefe at UCL. 

Behavioural studies of patients will build on our prior work showing that testing of spatial memory is highly sensitive for pre-dementia AD. These studies will include the development of novel tasks for testing the same behaviours across preclinical and clinical settings.

Imaging correlates of behavioural data will be obtained by analysis of hippocampal structure and connectivity obtained from high resolution MRI.

 

My research is closely aligned to clinical practice and at Addenbrooke’s Hospital I run a subspecialist Mild Cognitive Impairment Clinic in addition to my involvement in the Neurology-Psychiatry Memory Clinic.

Departments and Institutes

Clinical Neurosciences:

Research Interests

Alzheimer's disease

Mild cognitive impairment 

Entorhinal cortex and hippocampal function

MRI

Key Publications

Hopkins S, Chan D (2015) Key emerging issues in frontotemporal dementia. J Neurol (epub ahead of print)

 

MoodleyK, Perani D, Minati L, Della RosaP, PennycookF,  DicksonJ, BarnesA,  ContarinoV, MichopoulouS, D’Incerti L,  GoodC, FallancaF, VanoliE, EllP, Chan D (2015) Simultaneous PET-MRI studies of the concordance of atrophy and hypometabolism in syndromic variants of Alzheimer’s disease and frontotemporal dementia: an extended case series. J Alzheimer Disease (in press)

 

Chan D, Bottomley L, Hartley T, Burgess N (2015) The 4 Mountains Test: a short test of allocentric spatial memory with high sensitivity for the diagnosis of pre-dementia Alzheimer’s disease. J Visualized Experiments (in press)

 

Wood R, MoodleyK, Hodges JR, Allinson K, Spillantini MG, Chan D (2015) Slowly progressive behavioural presentation in two UK cases with the R406W MAPT mutation: a novel clinico-anatomical phenotype. Neuropathol Appl Neurobiol (in press)

 

Moodley K, Minati L, Contarino V, Prioni S, Wood R, Cooper R, D’Incerti L, Tagliavini F, Chan D. (2015) Diagnostic differentiation of mild cognitive impairment due to Alzheimer’s disease using a hippocampus-dependent test of spatial memory. Hippocampus 25, 939-951

 

Binks S, Chan D,Medford N (2015) Abolition of specific phobia: a novel consequence of left mesial temporal lobectomy. Neurocase 21, 79-84

 

Minati L, Chan D, Mastropasqua C, Serra L, Spano B, Marra C, Caltigirone C, Cerceignani M, Bozzali M (2014) Widespread alterations in functional brain network architecture in amnestic mild cognitive impairment. J Alzheimer Disease 40, 213-220

 

Chataway J, Alsanousi A, Chan D, MacManus D, Hunter K, Foster J, Bangham C, Wilkie D, Nicholas J, Clegg S, Nielsen C, Scheurer N, Calder V, Greenwood J, Frost C, Nicholas R (2014) The MS-STAT trial: High dose simvastatin demonstrates neuroprotection without immune-modulation in secondary progressive multiple sclerosis (SPMS) – a phase II trial. The Lancet 383, 2213-2221

 

Pfeifer G, Rothen N, Ward J, Chan D, Sigala N (2014) Associative memory advantage in grapheme-colour synaesthetes compared to older, but not younger, adults. Frontiers in Psychology 5, 696

 

Moodley K, Chan D (2014) The hippocampus in neurodegenerative disease. Front Neurol Neurosci 34, 95-108

 

Moodley K, Minati L, Barnes A, Dickson J, Ell P, Chan D (2013) Simultaneous PET-MRI in frontotemporal dementia. Eur J Nucl Med Mol Imaging 40, 468-469

 

Minati L, Varotto G, D'Incerti L, Panzica F, Chan D (2013) From brain topography to brain topology: relevance of graph theory to functional neuroscience. Neuroreport 24, 536-43

 

Minati L, Nigri A, Cercignani M, Chan D (2013) Detection of scale-freeness in brain connectivity by functional MRI: signal processing aspects and implementation of an open hardware co-processor. Med Eng Phys 35, 1525-1531

Minati L, Cercignani M, Chan D (2013) Rapid geodesic mapping of brain functional connectivity: implementation of a dedicated co-processor in a field-programmable gate array and application to resting state fMRI. Med Eng Phys 35, 1532-1539

Hopkins S, Moodley K, Chan D (2013) Encephalitis associated with antibodies to NMDA receptors presenting as relapsing acute psychosis. BMJ Case Rep pii:bcr20130101461

 

Bird CM, Chan D, Hartley T, Pijnenburg Y, Rossor MN, Burgess N (2010) Topographical short-term memory differentiates Alzheimer’s disease from frontotemporal lobar degeneration. Hippocampus 20, 1154-1169

 

Lehmann M, Douiri A, Kim L, Modat M, Chan D, Ourselin S, Barnes J, Fox N (2010) Atrophy patterns in Alzheimer’s disease and semantic dementia: a comparison of FreeSurfer and manual volumetric measurements. Neuroimage 49, 2264-2274

 

Chan D, Anderson VM, Pijnenburg Y, Whitwell JL, Barnes J, Scahill RI, Stevens JM, Barkhof F, Scheltens P, Rossor MN, Fox N (2009) The clinical profile of right temporal lobe atrophy. Brain 132, 1287-1298

 

Hartley T, Bird CM, Chan D, Cipolotti L, Husain M, Vargha-Khadem F, Burgess N (2007) Hippocampal damage selectively impairs topographical processing of spatial scenes over very short delays. Hippocampus 17, 34-48

 

Chan D, Henley S, Rossor MN, Warrington EK (2007) Temporally ungraded retrograde amnesia in encephalitis associated with antibodies to voltage-gated potassium channels. Archives of Neurology 64, 404-410

 

Chan D, Walters RJ, Sampson EL, Schott JM, Smith SJ, Rossor MN (2004) EEG abnormalities in frontotemporal lobar degeneration. Neurology 62, 1628-1630

 

Schott JM, Fox NC, Frost C, Scahill RI, Janssen JC, Chan D, Jenkins R, Rossor MN (2003) Cerebral atrophy in early familial Alzheimer’s disease: assessing the onset of structural change. Ann Neurol 53, 181-188

 

Chan D, Janssen JC, Whitwell J, Watt HC, Jenkins R, Frost C, Rossor MN, Fox NC (2003) Rates of cerebral atrophy in early onset Alzheimer’s disease increase with disease severity: a longitudinal MRI study. Lancet 362, 1121-1122

 

Högh P, Smith SJ, Scahill RI, Chan D, Harvey RJ, Fox NC, Rossor MN (2002) Epilepsy presenting as AD: Neuroimaging, electroclinical features and response to treatment. Neurology 58, 298-301

 

Good C, Scahill RI, Fox NC, Ashburner J, Friston KJ, Chan D, Crum WR, Rossor MN, Frackowiak RSJ (2002) Automatic differentiation of anatomical patterns in the human brain: validation with studies of degenerative dementias. Neuroimage 17, 29-46

 

Chan D, Fox NC, Rossor MN (2002) Differing patterns of temporal atrophy in Alzheimer's disease and semantic dementia. Neurology 58, 838

 

Chan D, Revesz T, Rudge P (2002) Hippocampal, but not parahippocampal, damage in a case of dense retrograde amnesia: a pathological study. Neurosci Lett  329, 61-64

 

Chan D, Rossor MN (2002)  "-But who is that on the other side of you?" Extracampine hallucinations revisited. Lancet 360, 2064-2067

 

Chan D, Fox NC, Scahill RI,  Crum WR, Whitwell J, Leschziner G, Rossor A, Stevens JM, L. Cipolotti L, Rossor MN (2001) Patterns of temporal lobe atrophy in semantic dementia and Alzheimer’s disease. Ann Neurol  49, 433-442

 

Chan D, Fox NC, Jenkins R, Scahill RI, Crum WR, Rossor MN (2001) Rates of regional and global cerebral atrophy in AD and frontotemporal dementia. Neurology 57, 1756-1763

 

Chan D, Crutch SJ, Warrington EK (2001) A disorder of colour perception associated with abnormal colour after-images: a defect of primary visual cortex. J Neurol Neurosurg Psychiatr 71, 515-517

 

Cipolotti L, Shallice T, Chan D, Fox NC, Scahill RI, Harrison G, Stevens JM, Rudge P (2001) Long term retrograde amnesia: the crucial role of the hippocampus. Neuropsychologia 39, 151-172