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Dr Amy Milton

Dr Amy Milton

University Lecturer, Department of Psychology

Ferreras-Willetts Fellow in Neuroscience, Downing College, Cambridge


Office Phone: (3)33593 (3)34853

Biography:

Amy Milton completed her PhD in Behavioural Neuroscience in the Department of Experimental Psychology at the University of Cambridge. She was a Research Fellow at Downing College, Cambridge from October 2007, until she was appointed to a Departmental Lectureship in the Department of Experimental Psychology in August 2008. She has been a University Lecturer since October 2013.

Departments and Institutes

Psychology:

Research Interests

Memory is a critical function of the brain, but surprisingly little is known about the mechanisms by which memories are modified, adapted, and persist. Memories are known to 'reconsolidate', undergoing updating and strengthening following their destabilisation at retrieval. I study the neurochemical, molecular and intracellular basis of the reconsolidation process, for aversive (fear) and appetitive (addictive drug) memories. Using translationally relevant animal models of neuropsychiatric disorders, such as post-traumatic stress disorder and drug addiction, I also focus on using this knowledge of memory reconsolidation mechanisms to develop treatments for these disorders, based on the disruption of maladaptive memories.

Key Publications

Merlo E, Ratano P, Ilioi E, Robbins MALS, Everitt BJ, Milton AL. (2015) Amygdala dopamine receptors are required for the destabilization of a reconsolidating appetitive memory. eNeuro e0024-14.2015 1-14.

Merlo E, Milton AL, Goozée ZY, Theobald DE, Everitt BJ. (2014) Reconsolidation and extinction are dissociable and mutually exclusive processes: behavioral and molecular evidence. J Neurosci 34(7):2422-31. 

Milton AL, Merlo E, Ratano P, Gregory BL, Dumbreck JK, Everitt BJ (2013). Double dissociation of the requirement for GluN2B- and GluN2A-containing NMDA receptors in the destabilization and restabilization of a reconsolidating memory. J Neurosci 33(3):1109-15

Milton AL, Everitt BJ (2012). The persistence of maladaptive memory: addiction, drug memories and anti-relapse treatments. Neurosci Biobehav Rev 36(4):1119-39.

Milton AL, Everitt BJ (2010). The psychological and neurochemical mechanisms of drug memory reconsolidation: implications for the treatment of addiction.  Eur J Neurosci 31(12):2308-19.