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Dr Emmanuel A Stamatakis

Dr  Emmanuel A Stamatakis

Stephen Erskine Fellow, Queens' College Cambridge

Lead, Functional Imaging Group, Division of Anaesthesia, School of Clinical Medicine, University of Cambridge

Visiting Senior Research Fellow, Centre for Speech, Language and the Brain, Dept. of Psychology, University of Cambridge

Visiting Scholar, Department of Education, University of Crete, Greece


Office Phone: +44 (0)1223 217890

Biography:

I have been working in the field of neuroimaging since I obtained a PhD in medical image analysis. My early work involved developing strategies for the quantification of abnormalities on brain perfusion SPECT and MRI images from head injured populations and relating those to behavioural outcomes. I joined the Centre for Speech, Language and the Brain at the University of Cambridge in 2001, where I developed, implemented and taught structural/functional imaging protocols in the context of a variety of cognitive neuroimaging projects aimed at establishing the neural substrates of language function. I have held the Stephen Erskine fellowship from Queens’ College, Cambridge since 2008. During this time, I have been based in the Division of Anaesthesia, University of Cambridge, pursuing research in the neural substrates of consciousness in awake and sedated volunteers and patients with traumatic brain injury. I lead the functional imaging team and mentor both graduate students and post-doctoral fellows.  

Departments and Institutes

Psychology:

Research Interests

My research aims to decode complex relationships between remote and/or proximal brain regions, which form networks at rest or during goal directed behaviour. This includes work on network adaptive behaviour (reorganisation/plasticity) triggered by abrupt (e.g. trauma, stroke) or gradual structural changes (e.g. neuropsychiatric/neurodegenerative diseases, ageing), or pharmacological agents. Although I primarily work with task related networks, I am also interested in the significance of resting networks and their relationship with task networks. In this context, my research questions are: Can resting network connectivity in individuals/groups provide insights to their ability to complete certain tasks? What happens to resting network connectivity during goal directed behaviour? How does structural integrity relate to network connectivity and behaviour? How do pharmacological agents modulate network organisation at rest or during tasks?

Key Publications

Vatansever D Menon DK, Manktelow AE, Sahakian BJ, Stamatakis EA (2015), “Default mode dynamics for global functional integration” Journal of Neuroscience (Accepted)

Vatansever D, Menon DK, Manktelow AE, Sahakian BJ, Stamatakis EA (in press), “Default mode network connectivity during task execution” Neuroimage 122:96-104

Meunier D, Stamatakis EA, Tyler LK (2014), “Age-related functional reorganization, structural changes, and preserved cognition.” Neurobiol Aging 35(1):42-54

Wright P, Stamatakis EA, Tyler LK (2012), “Differentiating hemispheric contributions to syntax and semantics in patients with left-hemisphere lesions.” J Neurosci 32(24):8149-57

Rolheiser T, Stamatakis EA, Tyler LK (2011), “Dynamic processing in the human language system: synergy between the arcuate fascicle and extreme capsule.” J Neurosci 31(47):16949-57

Stamatakis EA, Shafto MA, Williams G, Tam P, Tyler LK (2011), “White matter changes and word finding failures with increasing age.” PLoS One 6(1):e14496

Kasahara M, Menon DK, Salmond CH, Outtrim JG, Taylor Tavares JV, Carpenter TA, Pickard JD, Sahakian BJ, Stamatakis EA (2010), “Altered functional connectivity in the motor network after traumatic brain injury.” Neurology 75(2):168-76

Stamatakis EA, Adapa RM, Absalom AR, Menon DK (2010), “Changes in resting neural connectivity during propofol sedation.” PLoS One 5(12):e14224

Tyler LK, Wright P, Randall B, Marslen-Wilson WD, Stamatakis EA (2010), “Reorganization of syntactic processing following left-hemisphere brain damage: does right-hemisphere activity preserve function?” Brain 133(11):3396-408

Tyler LK, Shafto MA, Randall B, Wright P, Marslen-Wilson WD, Stamatakis EA (2010), “Preserving syntactic processing across the adult life span: the modulation of the frontotemporal language system in the context of age-related atrophy.” Cereb Cortex 20(2):352-64

Taylor KI, Stamatakis EA, Tyler LK (2009), “Crossmodal integration of object features: voxel-based correlations in brain-damaged patients.” Brain 132(Pt 3):671-83

Stamatakis EA, Marslen-Wilson WD, Tyler LK, Fletcher PC (2005), “Cingulate control of fronto-temporal integration reflects linguistic demands: a three-way interaction in functional connectivity.” Neuroimage 28(1):115-21

Tyler LK, Marslen-Wilson WD, Stamatakis EA (2005), “Differentiating lexical form, meaning, and structure in the neural language system.” Proc Natl Acad Sci U S A 102(23):8375-80

Tyler LK, Marslen-Wilson W, Stamatakis EA (2005), “Dissociating neuro-cognitive component processes: voxel-based correlational methodology.” Neuropsychologia 43(5):771-8

Stamatakis EA, Glabus MF, Wyper DJ, Barnes A, Wilson JT (1999), “Validation of statistical parametric mapping (SPM) in assessing cerebral lesions: A simulation study.” Neuroimage 10(4):397-407