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Lisa Ronan

Lisa Ronan

Office Phone: (7)64421

Departments and Institutes

Psychiatry:
Research Associate

Research Interests

My work focuses on structural analysis of the brain, in particular the morphology of the cortex. Most recently I have focused on cortical intrinsic curvature. This type of curvature is mathematically fundamental to a surface and independent of how it is folded (mean curvature). Cortical intrinsic curvature arises from the differential expansion of the surface during development, and may be related to the underlying architecture of the cortex as well as its tangential connectivity.

I am also interested in the mechanism of how the cortex develops its convoluted shape (gyrification), and the role of differential expansion in this process. 

By developing a deeper understanding of significance of cortical morphology through the use of mathematically fundamental parameters, it may be possible to more consistently distinguish case-control differences in diseases such as schizophrenia and autism, as well as subtle changes related to obesity, dyscalculia etc.

Key Publications

Ronan L, Fletcher PC, "From genes to folds: a review of cortical gyrification theory", BSF 2015

Ronan L, Voets N, Rua C, Alexander-Bloch A, Hough M, Mackay C, Crow T, James A, Giedd J, Fletcher P, “Differential Tangential Expansion as a Mechanism for Cortical Gyrification” Cereb Cortex

Ronan L, Pienaar R, Williams G, Bullmore E, Crow TJ, Roberts N, Jones PB, Suckling J, Fletcher PC (2011), “Intrinsic curvature: a marker of millimeter-scale tangential cortico-cortical connectivity?” Int J Neural Syst 21(5):351-66 Details