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Professor David Krishna Menon MD PhD FRCP FRCA FFICM FMedSci

Professor David Krishna Menon,  MD PhD FRCP FRCA FFICM FMedSci

Head, Division of Anaesthesia, University of Cambridge

Hon Consultant, Neurosciences Critical Care Unit, Addenbrooke’s Hospital

Professorial Fellow, Queens’ College, Cambridge

Senior Investigator, National Institute for Health Research, UK


Office Phone: 01223 217891

Biography:

David Krishna Menon trained in Medicine, Anaesthesia and Intensive Care at the Jawaharlal Institute in India, Leeds General Infirmary, The Royal Free Hospital and Addenbrooke's Hospital, and was an MRC Research Fellow at the Hammersmith Hospital prior to coming to Cambridge.  He is Professor and Head of the Division of Anaesthesia, Principal Investigator in the Wolfson Brain Imaging Centre, and Co-Chair of the Acute Brain Injury Program at the University of Cambridge; and Professorial Fellow in the Medical Sciences at Queens’ College, Cambridge.  In 2006 he was appointed to the British Oxygen Professorship at the Royal College of Anaesthetists. He serves on the Board of Management of the Intensive Care National Audit and Research Centre (ICNARC), as Co-Chair of  the Executive Board of the European Brain Injury Consortium, and on the Executive Board of the International Neurotrauma Society.  He is a Founding Fellow of the Academy of Medical Sciences, was  re-appointed Senior Investigator of the National Institute for Health Research (UK) for a second term in in 2014, and was appointed a member of the Founding Board of the UK Faculty of Intensive Care Medicine in 2010. He currently acts as one of two Coordinators of the CENTER-TBI project, a €30 million European multicentre study of precision medicine and comparative effectiveness research  in traumatic brain injury.

He was the first Director of the Neurosciences Critical Care Unit (NCCU) at Addenbrooke's Hospital, Cambridge, where he established the first recognised training program for specialist neurocritical care in the UK.  Protocols developed in the Addenbrooke’s NCCU have been shown to improve clinical outcome in severe head injury and rationalise the management of acute intracranial haemorrhage.

Professor Menon’s research interests include neurocritical care, secondary brain injury, neuroinflammation, and metabolic imaging of acute brain injury.  He has also published on the physiology of coma and the vegetative state, and on mechanisms of anaesthetic action in the brain. In recent years he has represented the UK intensive care community in discussions regarding the impact of evolving legislative changes on research in critical care and emergency medicine, and participated in national television and radio programs on research and ethical topics.  He has over a two hundred publications in peer reviewed journals, with a ‘h’ index of over 50, and has contributed to major textbooks.  Research in his group is supported by research funding from several sources, including the Academy of Medical Sciences, the Medical Research Council, the European Commission’s FP7 Program,  the Royal College of Anaesthetists, the Evelyn Trust, and the Wellcome Foundation. 

 

Departments and Institutes

Medicine:
Head, Division of Anaesthesia

Research Interests

Professor Menon’s research interests include neurocritical care, secondary brain injury, neuroinflammation, and metabolic imaging of acute brain injury.  He has also published on the physiology of coma and the vegetative state, and on mechanisms of anaesthetic action in the brain. In recent years he has represented the UK intensive care community in discussions regarding the impact of evolving legislative changes on research in critical care and emergency medicine, and participated in national television and radio programs on research and ethical topics.  He has over a two hundred publications in peer reviewed journals, with a ‘h’ index of over 50, and has contributed to major textbooks.  Research in his group is supported by research funding from several sources, including the Academy of Medical Sciences, the Medical Research Council, the European Commission’s FP7 Program,  the Royal College of Anaesthetists, the Evelyn Trust, and the Wellcome Foundation. 

Key Publications

Menon DK, Baudouin C, Tomlinson D, Hoyle C.  Proton Magnetic Resonance Spectroscopy and Imaging of the Brain in Acquired Immune Deficiency Syndrome.  J Comput Assist Tomogr 1990; 14:882-7.

Menon DK, Owen AM, Williams EJ, et al.  Cortical processing in persistent vegetative state.  Lancet 1998; 352: 200.

Coles JP, Fryer TD, Smielewski P, Chatfield DA, Steiner LA, Johnston AJ, Downey SP, Williams GB, Aigbirhio F, Hutchinson PJ, Rice K, Carpenter TA, Clark JC, Pickard JD, Menon DK.  Incidence and mechanisms of cerebral ischemia in early clinical head injury. J Cereb Blood Flow Metab 2004; 24:202-1

Menon DK, Coles JP, Gupta AK, Fryer TD, Smielewski P, Chatfield DA, Aigbirhio F, Skepper JN, Minhas PS, Hutchinson PJ, Carpenter TA, Clark JC, Pickard JD.  Diffusion limited oxygen delivery following head injury. Crit Care Med 2004;32:1384-90.

Cunningham AS, Salvador R, Coles JP, Chatfield DA, Bradley PG, Johnston AJ, Steiner LA, Fryer TD, Aigbirhio FI, Smielewski P, Williams GB, Carpenter TA, Gillard JH, Pickard JD, Menon DK.  Physiological thresholds for irreversible tissue damage in contusional regions following traumatic brain injury. Brain 2005;128:1931-42.

Davis MH, Coleman MR, Absalom AR, Rodd JM, Johnsrude IS, Matta BF, Owen AM, Menon DK.  Dissociating speech perception and comprehension at reduced levels of awareness. Proc Natl Acad Sci U S A 2007;104:16032-7.

Nortje J, Coles JP, Timofeev I, Fryer TD, Aigbirhio FI, Smielewski P, Outtrim JG, Chatfield DA, Pickard JD, Hutchinson PJA, Gupta AK, Menon DK. Effect of hyperoxia on regional oxygenation and metabolism following severe traumatic brain injury – preliminary findings. Critical Care Medicine 2008; 36:273-81

Menon DK, Schwab K, Wright DW, Maas AI; Demographics and Clinical Assessment Working Group of the International and Interagency Initiative toward Common Data Elements for Research on Traumatic Brain Injury and Psychological Health. Position statement: definition of traumatic brain injury. Arch Phys Med Rehabil 2010;91(11):1637-40.

Janowitz T, Menon DK. Exploring new routes for neuroprotective drug development in traumatic brain injury. Sci Transl Med 2010 Apr 14;2(27):27rv1.

Newcombe VF, Outtrim JG, Chatfield DA, Manktelow A, Hutchinson PJ, Coles JP, Williams GB, Sahakian BJ, Menon DK. Parcellating the neuroanatomical basis of impaired decision-making in traumatic brain injury. Brain 2011;134:759-68.

Harrison DA, Prabhu G, Grieve R, Harvey SE, Sadique MZ, Gomes M, Griggs KA, Walmsley E, Smith M, Yeoman P, Lecky FE, Hutchinson PJ, Menon DK, Rowan KM. Risk Adjustment In Neurocritical care (RAIN)--prospective validation of risk prediction models for adult patients with acute traumatic brain injury to use to evaluate the optimum location and comparative costs of neurocritical care: a cohort study. Health Technol Assess. 2013; 17(23): vii-viii, 1-350.

Hong YT, Veenith T, Dewar D, Outtrim JG, Mani V, Williams C, Pimlott S, Hutchinson PJ, Tavares A, Canales R, Mathis CA, Klunk WE, Aigbirhio FI, Coles JP, Baron JC, Pickard JD, Fryer TD, Stewart W, Menon DK. Amyloid imaging with carbon  11-labeled Pittsburgh compound B for traumatic brain injury. JAMA Neurol 2014; 71(1):23-31.

Newcombe VF, Correia MM, Ledig C, Abate MG, Outtrim JG, Chatfield D, Geeraerts T, Manktelow AE, Garyfallidis E, Pickard JD, Sahakian BJ, Hutchinson PJ, Rueckert D, Coles JP, Williams GB, Menon DK. Dynamic Changes in White Matter Abnormalities Correlate With Late Improvement and Deterioration Following TBI: A Diffusion Tensor Imaging Study. Neurorehabil Neural Repair. 2015 Apr 28.[Epub ahead of print] PubMed PMID: 25921349.